I think this Selfnamed serum is the epicenter of all K-beauty trends in one product. Spicules are tiny micro needles that create a light tingling sensation, improve product absorption and gently exfoliate the skin. The PDRN in this formula is biosynthesized, so there are no animal particles in it, and it works toward the same renewal as salmon PDRN. Centella asiatica, also known as Sika, helps promote skin renewal and calms the skin after the tingling. Together, I believe they make a great serum for signs of aging and uneven texture, with improved smoothness, firmness, tone and texture. It can be used every day after cleansing and before a moisturizer.